More than an Anti-diabetic Bariatric Surgery, Metabolic Surgery Alleviates Systemic and Local Inflammation in Obesity

被引:34
作者
Zhang, Chunlan [1 ,2 ,3 ,4 ]
Zhang, Jingjing [1 ,2 ,3 ,4 ]
Liu, Zhenqi [5 ]
Zhou, Zhiguang [1 ,2 ,3 ,4 ]
机构
[1] Cent South Univ, Dept Endocrinol & Metab, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
[2] Metab Syndrome Res Ctr, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Key Lab Diabet Immunol, Minist Educ, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Changsha 410011, Hunan, Peoples R China
[5] Univ Virginia Hlth Syst, Div Endocrinol & Metab, Dept Med, Charlottesville, VA USA
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
Bariatric surgery; Inflammation; Obesity; Type; 2; diabetes; Y GASTRIC BYPASS; SUBCUTANEOUS ADIPOSE-TISSUE; LAPAROSCOPIC SLEEVE GASTRECTOMY; INTENSIVE MEDICAL THERAPY; ENDOPLASMIC-RETICULUM STRESS; PROMOTE INSULIN-RESISTANCE; MESSENGER-RNA EXPRESSION; TYPE-2; DIABETES-MELLITUS; INDUCED WEIGHT-LOSS; T-CELL;
D O I
10.1007/s11695-018-3400-z
中图分类号
R61 [外科手术学];
学科分类号
摘要
Obesity, associated with increased risk of type 2 diabetes (T2D), cardiovascular disease, and hepatic steatosis et al., has become a major global health problem. Recently, obesity has been proven to be under a status of low-grade, chronic inflammation, which contributes to insulin resistance and T2D. Bariatric surgery is currently an effective treatment for the control of morbid obesity and T2D, which impels ongoing efforts to clarify physiological and molecular mechanisms mediating these benefits. The correlation between obesity, inflammation, and T2D has been revealed to a certain extent, and studies have shed light on the effect of bariatric surgery on inflammatory status of subjects with obesity. Based on recent findings, this review focuses on the relationship between inflammation, obesity, and bariatric surgery.
引用
收藏
页码:3658 / 3668
页数:11
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