Synthesis of N,N-disubstituted 1-cyanocyclopropanecarboxamides

被引：5
|
作者：
Yamagata, K [1 ]
Okabe, F [1 ]
Tagawa, Y [1 ]
机构：
[1] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 13期
关键词：
acetyl chloride; cyclization; cyclopropanes; furans; ring opening;
D O I：
10.1002/ejoc.200200516
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-(Disubstituted amino) -4,5-dihydro-3-furancarbonitriles 1a-i reacted with acetyl chloride to yield the corresponding ring-opening products 2a-i The cyclization of compounds 2a-i with bases gave the corresponding N,N-disubstituted 1-cyanocyclopropanecarboxamides 3a-c and (E)-1-cyano-2-phenylcyclopropanecarboxamides MA The same compounds 3d-f were also obtained by treatment of compounds 2g-i with sodium methoxide. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
引用
收藏
页码：2383 / 2387
页数：5
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