Synthesis of N,N-disubstituted 1-cyanocyclopropanecarboxamides

被引：5

作者：

Yamagata, K ^{[1
]}

Okabe, F ^{[1
]}

Tagawa, Y ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 13期

关键词：

acetyl chloride; cyclization; cyclopropanes; furans; ring opening;

D O I：

10.1002/ejoc.200200516

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(Disubstituted amino) -4,5-dihydro-3-furancarbonitriles 1a-i reacted with acetyl chloride to yield the corresponding ring-opening products 2a-i The cyclization of compounds 2a-i with bases gave the corresponding N,N-disubstituted 1-cyanocyclopropanecarboxamides 3a-c and (E)-1-cyano-2-phenylcyclopropanecarboxamides MA The same compounds 3d-f were also obtained by treatment of compounds 2g-i with sodium methoxide. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

引用

页码：2383 / 2387

页数：5

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