Biodegradable, Tissue Adhesive Polyester Blends for Safe, Complete Wound Healing

被引：20
作者：
Daristotle, John L. [1 ]
Erdi, Metecan [2 ]
Lau, Lung W. [3 ]
Zaki, Shadden T. [4 ]
Srinivasan, Priya [3 ]
Balabhadrapatruni, Manogna [2 ]
Ayyub, Omar B. [2 ]
Sandler, Anthony D. [3 ]
Kofinas, Peter [2 ]
机构：
[1] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA
[2] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA
[3] Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Joseph E Robert Jr Ctr Surg Care, Washington, DC 20010 USA
[4] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA
来源：
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2021年 / 7卷 / 08期
基金：
美国国家卫生研究院;
关键词：
tissue adhesion; wound healing; biodegradable adhesive; sprayable polymer; bandage; ALLERGIC CONTACT-DERMATITIS; SURGICAL SEALANT; DRESSINGS; POLYMER; REPAIR;
D O I：
10.1021/acsbiomaterials.1c00865
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Pressure-sensitive adhesives typically used for bandages are nonbiodegradable, inhibiting healing, and may cause an allergic reaction. Here, we investigated the effect of biodegradable copolymers with promising thermomechanical properties on wound healing for their eventual use as biodegradable, biocompatible adhesives. Blends of low molecular weight (LMW) and high molecular weight (HMW) poly(lactide-co-caprolactone) (PLCL) are investigated as tissue adhesives in comparison to a clinical control. Wounds treated with PLCL blend adhesives heal completely with similar vascularization, scarring, and inflammation indicators, yet require fewer dressing changes due to integration of the PLCL adhesive into the wound. A blend of LMW and HMW PLCL produces an adhesive material with significantly higher adhesive strength than either neat polymer. Wound adhesion is comparable to a polyurethane bandage, utilizing conventional nonbiodegradable adhesives designed for extremely strong adhesion.
引用
收藏
页码：3908 / 3916
页数：9
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