Genetics of diabetic nephropathy

被引：10

作者：

Merta, M ^{[1
]}

Reiterova, J ^{[1
]}

Rysavá, R ^{[1
]}

Kmentová, D ^{[1
]}

Tesar, V ^{[1
]}

机构：

[1] Charles Univ, Fac Med 1, Dept Med 1, Prague 12808 2, Czech Republic

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2003年 / 18卷

关键词：

diabetes; diabetic nephropathy; genes; gene polymorphism; IDDM; NIDDM;

D O I：

10.1093/ndt/gfg1038

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Diabetic nephropathy (DN) develops in similar to40% of type 1 diabetic patients and is a leading cause of end-stage renal failure. Its rate of progression varies greatly among individuals. Several factors, including genetic predisposition, metabolic and haemodynamic alterations and various growth factors, may contribute to the initiation and progression of DN. The genetic background of DN is believed to be polygenic. Polymorphisms of different genes, mainly from the renin-angiotensin system, have been studied extensively, and some of them have been suggested to contribute to the development of DN. A search for genes and combinations of genes which could influence the development and progression of DN is in progress.

引用

页码：24 / 25

页数：2

共 7 条

[1]

Diabet Control Complications Trial Res Grp, 1997, DIABETES, V46, P1829

[2] The role of genetic susceptibility in diabetic nephropathy: evidence from family studies [J].

Fava, S ;

Hattersley, AT .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2002, 17 (09) :1543-1546

[3]

Hanson RL, 2001, DIABETES-METAB RES, V17, P296, DOI 10.1002/dmrr.213

[4] Genetics of diabetic nephropathy: Evidence for major and minor gene effects [J].

Krolewski, AS .

KIDNEY INTERNATIONAL, 1999, 55 (04) :1582-1596

[5] Pathogenesis of diabetic nephropathy [J].

Raptis, AE ;

Viberti, G .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2001, 109 :S424-S437

[6] Diabetic nephropathy and the insertion/deletion polymorphism of the angiotensin-converting enzyme gene [J].

Tarnow, L ;

Gluud, C ;

Parving, HH .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1998, 13 (05) :1125-1130

[7] Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism [J].

Zanchi, A ;

Moczulski, DK ;

Hanna, LS ;

Wantman, M ;

Warram, JH ;

Krolewski, AS .

KIDNEY INTERNATIONAL, 2000, 57 (02) :405-413

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