THE EFFECTS OF SWIMMING EXERCISE ON PLASMA IRISIN, ADROPIN, INSULIN, LEPTIN LEVELS AND LIPID PARAMETERS IN RATS WITH METABOLIC SYNDROME

This study was performed to investigate the effects of swimming exercise on plasma insulin, leptin, irisin, adropin levels and biochemical parameters in rats with metabolic syndrome. The wistar albino rats were divided into 2 groups; control group and the metabolic syndrome (MetS) group. Control group fed with standard chow diet, MetS group fed with 20% fructose in drinking water for 12 weeks. After then, control and MetS groups were divided into two sub-groups including exercise and non-exercise. Swimming exercise was performed for 30 minutes a day for 4 weeks. After exercise program, the rats in all groups were weighed and euthanized and then their plasma hormone levels were determined by EIA method, their biochemical parameters were determined by spectrofotometric method. In MetS group, increased glucose, total cholesterol, LDL, trigliserid (P<0.05) and decreased HDL were determined. An increase was observed in leptin, insulin (P<0.05) and irisin levels, while declines in adropin levels (P<0.05). At the end of the exercise protocol, it was determined that exercise reduces glucose level in rats with MetS (P<0.05). Also, a slight decrease in insulin, irisin, leptin and adropin levels were observed. Although plasma leptin and irisin levels increased on MetS group, body mass index, leptin and irisin levels decreased on MetS-Exercise groups. In conclusions, although chronic short term exercise positively affected glucose and insulin levels, it did not cause any changes in hormone levels. It is suggested that new studies in which the durations of exercise in addition to different types of exercises change need to be done in order to the effects of new hormones especially such as irisin and adropin in MetS and its treatment,