In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

被引：67
作者：
Kim, YC
Oh, H
Kim, BS
Kang, TH
Ko, EK
Han, YM
Kim, BY
Ahn, JS
机构：
[1] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea
[2] Wonkwang Univ, Phytofermentat Res Ctr, Iksan, South Korea
[3] Wonkwang Univ, Coll Pharm, Iksan, South Korea
来源：
PLANTA MEDICA | 2005年 / 71卷 / 01期
关键词：
D O I：
10.1055/s-2005-837759
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 113 as an attractive therapeutic target for diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1 B activity in a dose-dependent manner, displaying IC50 values of 9.4 +/- 0.5 muM and 20.8 +/- 1.9 muM, respectively.
引用
收藏
页码：87 / 89
页数：3
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