Cu(ii)-Mediated aerobic oxidative synthesis of sulfonated chromeno[4,3-c]pyrazol-4(2H)-ones

被引：6

作者：

Zhou, Quan ^{[1
,2
]}

Yu, Hai-Yan ^{[1
,2
]}

Zhou, Yaqing ^{[3
]}

Wei, Jing-Ru ^{[1
,2
]}

Wang, Lei ^{[1
,2
,4
]}

机构：

[1] Taizhou Univ, Adv Res Inst, Taizhou 318000, Zhejiang, Peoples R China

[2] Taizhou Univ, Dept Chem, Taizhou 318000, Zhejiang, Peoples R China

[3] Taizhou Jiaxin Metering & Testing Co Ltd, Dept Chem, Taizhou 317000, Zhejiang, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 28期

基金：

中国国家自然科学基金;

关键词：

SELECTIVE INHIBITORS; DERIVATIVES; CYCLIZATION; DISCOVERY; COUMARIN; CARBONYL; LIGANDS; POTENT;

D O I：

10.1039/d2ob00639a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, starting with propiolates and sulfonyl hydrazides, we developed a concise and facile synthesis of 2-sulfonylated chromeno [4,3-c]pyrazol-4(2H)-ones or 2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-ones via Cu(ii)-promoted oxidative cascade C-C/C-N bond formation. This protocol has the advantages of atom economy and good functional group tolerance. The primary mechanism studies indicate that the reaction involves a free-radical process as well as terminal alkyne C-H activation.

引用

页码：5575 / 5581

页数：7

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