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Comparison of the time to analgetic and anti-inflammatory effect in the treatment of gouty arthritis with nimesulide and sodium diclofenac
被引:0
作者:
Kudaeva, F. M.
[1
]
Eliseev, M. S.
[1
]
Barskova, V. G.
[1
]
Nasonova, V. A.
[1
]
机构:
[1] Inst Rheumatol, Moscow, Russia
关键词:
gout;
nimesulide;
sodium diclofenac;
pain;
inflammation;
D O I:
暂无
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Aim. To compare the time to presentation of the analgetic and anti-inflammatory effects of granulated and tablet nimesulide and sodium diclofenac since the start of therapy for gouty arthritis (GA). Material and methods. Ninety males with gout were randomized into 3 equal groups. The patients were included in the study by the following criteria: a documented diagnosis of gout (Wallace S. criteria), age over 18 years, acute arthritis for less than 3 weeks, affection of 4 and more joints. For 7 days patients of group 1 received nimesil (200 mg/day), those of group 2 - aponil (200 mg/day), group 3 - sodium diclofenac (150 mg/day). Swelling, articular, pain indices were estimated daily for 7 days. Results. Patients of group I (nimesil) experienced pain relief on min 20; patients taking nimesulide (aponil) experienced pain attenuation within the first hour. Pain (at rest and movement) and the indices declined faster in group 1 than in group 2 as well as in groups 1 and 2 compared to group 3. Arthritis was arrested in 24 (80%) patients of group 1, 11 (36%) of group 2 and 4 (13%) of group 3. Conclusion. Efficacy of nimesulide for arrest of an acute gout attack exceeds that of sodium diclofenac. Granulated nimesulide has advantages over tablets.
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页码:35 / 40
页数:6
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