Relationship between α7 nAChR and apoptosis in human lymphocytes

被引：65
|
作者：
De Rosa, MJ [1 ]
Esandi, MD [1 ]
Garelli, A [1 ]
Rayes, D [1 ]
Bouzat, C [1 ]
机构：
[1] UNS, CONICET, Inst Invest Bioquim Bahia Blanca, Bahia Blanca, Argentina
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 160卷 / 1-2期
关键词：
lymphocyte; alpha 7 nicotinic receptor; apoptosis; nicotine;
D O I：
10.1016/j.jneuroim.2004.11.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The presence of nicotinic receptors (nAChRs) in blood cells has been demonstrated. However, little is known about their functional roles. We have detected mRNA of alpha 7 nAChR in peripheral human lymphocytes and determined that its expression is highly variable among individuals and within the same individual at different times. Upregulation of alpha 7 is systematically observed after incubation of lymphocytes with nicotine or alpha-bungarotoxin. In addition, the incubation with these drugs decreases the percentage of apoptotic cells induced by the exposure to cortisol. Our results suggest that alpha 7 nAChRs are involved in the modulation of cortisol-induced apoptosis. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：154 / 161
页数：8
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