Synthesis of Novel Chitin Derivatives Bearing Amino Groups and Evaluation of Their Antifungal Activity

被引:6
|
作者
Zhang, Jingjing [1 ,2 ]
Luan, Fang [3 ]
Li, Qing [1 ]
Gu, Guodong [4 ]
Dong, Fang [1 ]
Guo, Zhanyong [1 ,2 ]
机构
[1] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Shandong Jiaotong Univ, Nav Coll, Weihai 264209, Peoples R China
[4] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
来源
MARINE DRUGS | 2018年 / 16卷 / 10期
基金
中国国家自然科学基金;
关键词
6-amino-chitin; 3,6-diamino-chitin; antifungal activity; chitin derivative; structure characteristics; CHITOSAN DERIVATIVES; IN-VITRO; ANTIOXIDANT ACTIVITIES; ANTIBACTERIAL ACTIVITY; EXTRACTION; PRODUCTS; 6-AMINO-6-DEOXYCHITOSAN; NANOPARTICLES; PRECURSORS; INULIN;
D O I
10.3390/md16100380
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Chemical modification is one of the most effective methods to improve the biological activity of chitin. In the current study, we modified C3-OH and C6-OH of chitin (CT) and successfully synthesized 6-amino-chitin (NCT) and 3,6-diamino-chitin (DNCT) through a series of chemical reactions. The structure of NCT and DNCT were characterized by elemental analyses, FT-IR, C-13 NMR, XRD, and SEM. The inhibitory effects of CT, NCT, and DNCT against six kinds of phytopathogen (F. oxysporum f. sp. cucumerium, B. cinerea, C. lagenarium, P. asparagi, F. oxysporum f. niveum, and G. zeae) were evaluated using disk diffusion method in vitro. Meanwhile, carbendazim and amphotericin B were used as positive controls. Results revealed that 6-amino-chitin (NCT) and 3,6-diamino-chitin (DNCT) showed improved antifungal properties compared with pristine chitin. Moreover, DNCT exhibited the better antifungal property than NCT. Especially, while the inhibition zone diameters of NCT are ranged from 11.2 to 16.3 mm, DNCT are about 11.4-20.4 mm. These data demonstrated that the introduction of amino group into chitin derivatives could be key to increasing the antifungal activity of such compounds, and the greater the number of amino groups in the chitin derivatives, the better their antifungal activity was.
引用
收藏
页数:11
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