Protease-Activated Drug Development

被引：185
作者：
Choi, Ki Young [1 ]
Swierczewska, Magdalena [1 ,2 ]
Lee, Seulki [1 ]
Chen, Xiaoyuan [1 ]
机构：
[1] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
[2] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA
来源：
THERANOSTICS | 2012年 / 2卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Protease; activatable probe; Alzheimer's disease; cancer; caspase; cathepsin; kallikrein; MMP; PSA; serine protease; aspartyl protease; PROSTATE-SPECIFIC ANTIGEN; ALBUMIN-BINDING PRODRUG; L-LEUCYL-DOXORUBICIN; SENSITIVE PHOTODYNAMIC AGENTS; COPOLYMER-BOUND ADRIAMYCIN; SQUAMOUS-CELL CARCINOMAS; TRANSGENIC MOUSE MODEL; BREAST-CANCER PATIENTS; HUMAN CATHEPSIN-B; MATRIX METALLOPROTEINASES;
D O I：
10.7150/thno.4068
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In this extensive review, we elucidate the importance of proteases and their role in drug development in various diseases with an emphasis on cancer. First, key proteases are introduced along with their function in disease progression. Next, we link these proteases as targets for the development of prodrugs and provide clinical examples of protease-activatable prodrugs. Finally, we provide significant design considerations needed for the development of the next generation protease-targeted and protease-activatable prodrugs.
引用
收藏
页码：156 / 178
页数：23
相关论文
共 269 条
  • [21] Brömme D, 2009, EXPERT OPIN INV DRUG, V18, P585, DOI [10.1517/13543780902832661 , 10.1517/13543780902832661]
  • [22] DEGRADATION OF EXTRACELLULAR-MATRIX PROTEINS BY HUMAN CATHEPSIN-B FROM NORMAL AND TUMOR-TISSUES
    BUCK, MR
    KARUSTIS, DG
    DAY, NA
    HONN, KV
    SLOANE, BF
    [J]. BIOCHEMICAL JOURNAL, 1992, 282 : 273 - 278
  • [23] CAMPO E, 1994, AM J PATHOL, V145, P301
  • [24] Polymeric photosensitizer prodrugs for photodynamic therapy
    Campo, Marino A.
    Gabriel, Doris
    Kucera, Pavel
    Gurny, Robert
    Lange, Norbert
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2007, 83 (04) : 958 - 965
  • [25] The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
    Cardone, RA
    Casavola, V
    Reshkin, SJ
    [J]. NATURE REVIEWS CANCER, 2005, 5 (10) : 786 - 795
  • [26] PROTEASE-ACTIVATED PRODRUGS FOR CANCER-CHEMOTHERAPY
    CARL, PL
    CHAKRAVARTY, PK
    KATZENELLENBOGEN, JA
    WEBER, MJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04): : 2224 - 2228
  • [27] A NOVEL CONNECTOR LINKAGE APPLICABLE IN PRODRUG DESIGN
    CARL, PL
    CHAKRAVARTY, PK
    KATZENELLENBOGEN, JA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (05) : 479 - 480
  • [28] Carter PJ, 2001, CASPASE ACTIVATED PR
  • [29] Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells
    Cavallo-Medved, D
    Mai, JX
    Dosescu, J
    Sameni, M
    Sloane, BF
    [J]. JOURNAL OF CELL SCIENCE, 2005, 118 (07) : 1493 - 1503
  • [30] Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology
    Chakrabarti, S
    Patel, KD
    [J]. EXPERIMENTAL LUNG RESEARCH, 2005, 31 (06) : 599 - 621
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