Regio- and stereoselective 12-O-demethylation of schizandrin into gomisin T, an important intermediate to gomisin A, by Mortierella sp (TM-I1104)

被引：4

作者：

Kanatani, H

Terabayashi, S

Takeda, S

Li, W

Koike, K

Nikaido, T

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

[2] Tsumura & Co, Cent Res Labs, Ami, Ibaraki 3001192, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 49期

关键词：

biotransformation; Mortierella; TM-I1104; Cunninghamella; schizandrin; gomisin T; gomisin A; O-demethylation;

D O I：

10.1016/j.tetlet.2005.10.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strain TM-11104 identified as Mortierella sp. was discovered from soil as the most efficient fungus, which converted schizandrin into gomisin T in 91% regioselectivity by microbial 12-O-demethylation. Under optimum conditions, the yield of gomisin T reached around 80%. The faculty of 12-O-demethylation was specific on (+)-schizandrin (natural form) and the optical purity of gomisin T converted from (+)-schizandrin was 96% ee. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8467 / 8470

页数：4

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