The interplay between stress and growth in solid tumors

被引：38

作者：

Ambrosi, D. ^{[1
]}

Preziosi, L. ^{[2
]}

Vitale, G. ^{[2
]}

机构：

[1] Politecn Milan, MOX Dipartimento Matemat, I-20133 Milan, Italy

[2] Politecn Torino, Dipartimento Matemat, I-10124 Turin, Italy

来源：

MECHANICS RESEARCH COMMUNICATIONS | 2012年 / 42卷

关键词：

Continuum mechanics; Biology; Tumors; Growth; Mechanotrasduction; MODULATED GROWTH; TISSUES; BALANCE;

D O I：

10.1016/j.mechrescom.2012.01.002

中图分类号：

O3 [力学];

学科分类号：

08 ; 0801 ;

摘要：

A number of biological phenomena are interlaced with classical mechanics. In this review we discuss the role of mechanics in tumor growth, namely the avascular phase of solid tumors. While a growing mass produces a traction of the surrounding tissues, a feedback mechanism controls the proliferation of the malignant cells depending on the tensional state. The formalism of continuum mechanics, possibly accompanied by numerical simulations, is able to shed light on biological controversial subjects. The converse is also true: non-standard mechanical problems suggest new challenging theoretical questions. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：87 / 91

页数：5

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