Cymatherelactone and cymatherols A-C, polycyclic oxylipins from the marine brown alga Cymathere triplicata

被引：11

作者：

Choi, Hyukjae ^{[1
]}

Proteau, Philip J. ^{[2
]}

Byrum, Tara ^{[1
]}

Gerwick, William H. ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

[2] Oregon State Univ, Coll Pharm, Dept Pharmaceut Sci, Corvallis, OR 97331 USA

来源：

PHYTOCHEMISTRY | 2012年 / 73卷

关键词：

Cymathere triplicata; Brown alga; Oxylipin; Sodium channel inhibition; LAURENCIA-HYBRIDA; METABOLITES; BIOASSAY;

D O I：

10.1016/j.phytochem.2011.09.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An investigation of the oxylipin chemistry of the temperate brown alga Cymathere triplicata led to the isolation of several secondary metabolites, cymatherelactone (1) and cymatherols A-C (2-4), the latter as their methyl ester derivatives (5-7), which contained cyclopentyl, cyclopropyl, epoxide and lactone rings. Their structures were elucidated using a combination of spectroscopic techniques and synthetic chemistry. Cymatherelactone (1), as well as R- and S-Mosher's esters of its seco acid, exhibited moderate sodium channel blocking activity. (C) 2011 Published by Elsevier Ltd.

引用

页码：134 / 141

页数：8

共 15 条

[1] THE STEREOCHEMISTRY AND BIOSYNTHESIS OF HYBRIDALACTONE, AN EICOSANOID FROM LAURENCIA-HYBRIDA [J].