Metabolomics and bladder cancer

被引：19
作者：
Hyndman, Matthew E. [1 ]
Mullins, Jeffrey K. [1 ]
Bivalacqua, Trinity J. [1 ]
机构：
[1] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Abaltimore, MD 21287 USA
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2011年 / 29卷 / 05期
关键词：
Metabolomics; Bladder cancer; Cytology; Cystoscopy; Diagnosis; Review; HPLC; NMR; Urine; PROSTATE-CANCER; BREAST-CANCER; HUMAN URINE; SPECTROSCOPY; DIAGNOSIS; METABOLITES; CARCINOMA; CITRATE; MEN;
D O I：
10.1016/j.urolonc.2011.05.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Diagnosis of bladder cancer is primarily made based on clinical presentation and then by direct visualization with cystoscopy. Despite the massive investments recently made to identify urinary-based assays that are able to diagnosis urothelial carcinoma, urine cytology and cystoscopy still remain the gold standard. Recently proof of principle studies have shown that noninvasive urine-based metabolomics, using high pressure liquid chromatography (HPLC) and nuclear magnetic resonance (NMR), may be able to accurately diagnosis bladder cancer. This review discuses the published studies investigating metabolomics and bladder cancer and the future potential of this developing field. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：558 / 561
页数：4
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