Advances in Systemic Therapy for Metastatic or Advanced Gastric Cancer

被引：21

作者：

Shitara, Kohei ^{[1
]}

Ohtsu, Atsushi ^{[1
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Gastrointestinal Oncol, Kashiwa, Chiba, Japan

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2016年 / 14卷 / 10期

关键词：

RANDOMIZED PHASE-III; DOUBLE-BLIND; 1ST-LINE THERAPY; PLUS PACLITAXEL; OPEN-LABEL; SUPPORTIVE CARE; TRIAL; ADENOCARCINOMA; CHEMOTHERAPY; CAPECITABINE;

D O I：

10.6004/jnccn.2016.0138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In recent years, various new agents have been investigated for the treatment of advanced gastric cancer (AGC). The anti-HER2 antibody trastuzumab has been shown to prolong the overall survival of patients with HER2-positive AGC and has become a standard treatment. However, lapatinib, or ado-trastuzumab emtansine (T-DM1), did not show survival benefit in AGC, although it has shown remarkable efficacy for HER2-positive breast cancer. The efficacy of the anti vascular endothelial growth factor receptor monoclonal antibody ramucirumab for pretreated gastric cancer is a milestone for antiangiogenic therapy for AGC. Early clinical trials of TAS-118, TAS-102, and STAT3 inhibitors; IMAB362 (anti Claudin 18.2); and immune checkpoint inhibitors are all encouraging. These findings warrant further evaluation in larger clinical trials.

引用

页码：1313 / 1320

页数：8

共 52 条

[1]

Al-Batran S-E, 2016, J CLIN ONCOL S, V34

[2]

[Anonymous], J CLIN ONCOL S

[3]

[Anonymous], J CLIN ONCOL S

[4]

[Anonymous], ASCO M

[5] A multicenter phase II study of TAS-102 monotherapy in patients with pre-treated advanced gastric cancer (EPOC1201) [J].

Bando, Hideaki ;

Doi, Toshihiko ;

Muro, Kei ;

Yasui, Hirofumi ;

Nishina, Tomohiro ;

Yamaguchi, Kensei ;

Takahashi, Shunji ;

Nomura, Shogo ;

Kuno, Hirofumi ;

Shitara, Kohei ;

Sato, Akihiro ;

Ohtsu, Atsushi .

EUROPEAN JOURNAL OF CANCER, 2016, 62 :46-53

[6]

Bang YJ, 2010, LANCET, V376, P1302

[7] Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer [J].

Bang, Yung-Jue ;

Im, Seock-Ah ;

Lee, Keun-Wook ;

Cho, Jae Yong ;

Song, Eun-Kee ;

Lee, Kyung Hee ;

Kim, Yeul Hong ;

Park, Joon Oh ;

Chun, Hoo Geun ;

Zang, Dae Young ;

Fielding, Anitra ;

Rowbottom, Jacqui ;

Hodgson, Darren ;

O'Connor, Mark J. ;

Yin, Xiaolu ;

Kim, Woo Ho .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (33) :3858-+

[8] Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

[9] Phase Ib/II study of cancer stem cell (CSC) inhibitor BBI608 combined with paclitaxel in advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma. [J].

Becerra, Carlos ;

Stephenson, Joe ;

Jonker, Derek J. ;

Cohn, Allen Lee ;

Asmis, Timothy R. ;

Bekaii-Saab, Tanios S. ;

Conkling, Paul R. ;

Garbo, Lawrence E. ;

Lenz, Heinz-Josef ;

Richards, Donald A. ;

Spira, Alexander I. ;

Mikhail, Sameh ;

Goodwin, Rachel Anne ;

Yoon, Harry H. ;

Hume, Stephanie ;

Hitron, Matthew ;

Li, Chiang .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)

[10] Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes [J].

Cristescu, Razvan ;

Lee, Jeeyun ;

Nebozhyn, Michael ;

Kim, Kyoung-Mee ;

Ting, Jason C. ;

Wong, Swee Seong ;

Liu, Jiangang ;

Yue, Yong Gang ;

Wang, Jian ;

Yu, Kun ;

Ye, Xiang S. ;

Do, In-Gu ;

Liu, Shawn ;

Gong, Lara ;

Fu, Jake ;

Jin, Jason Gang ;

Choi, Min Gew ;

Sohn, Tae Sung ;

Lee, Joon Ho ;

Bae, Jae Moon ;

Kim, Seung Tae ;

Park, Se Hoon ;

Sohn, Insuk ;

Jung, Sin-Ho ;

Tan, Patrick ;

Chen, Ronghua ;

Hardwick, James ;

Kang, Won Ki ;

Ayers, Mark ;

Dai Hongyue ;

Reinhard, Christoph ;

Loboda, Andrey ;

Kim, Sung ;

Aggarwal, Amit .

NATURE MEDICINE, 2015, 21 (05) :449-U217

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