New-Onset Atrial Fibrillation and Early Mortality Rate in COVID-19 Patients: Association with IL-6 Serum Levels and Respiratory Distress

被引：14

作者：

Bagnato, Gianluca ^{[1
]}

Imbalzano, Egidio ^{[1
]}

Aragona, Caterina Oriana ^{[1
]}

Ioppolo, Carmelo ^{[1
]}

Di Micco, Pierpaolo ^{[2
]}

La Rosa, Daniela ^{[1
]}

Costa, Francesco ^{[3
]}

Micari, Antonio ^{[3
]}

Tomeo, Simona ^{[1
]}

Zirilli, Natalia ^{[1
]}

Sciacqua, Angela ^{[4
]}

D'Angelo, Tommaso ^{[3
]}

Cacciola, Irene ^{[1
]}

Bitto, Alessandra ^{[1
]}

Irrera, Natasha ^{[1
]}

Russo, Vincenzo ^{[5
]}

Roberts, William Neal ^{[6
]}

Gangemi, Sebastiano ^{[1
]}

Versace, Antonio Giovanni ^{[1
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, I-98125 Messina, Italy

[2] Buonconsiglio Fatebenefratelli Hosp, Dept Med, I-80122 Naples, Italy

[3] Univ Messina, BIOMORF Dept, I-98125 Messina, Italy

[4] Univ Magna Grcia Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy

[5] Univ Campania Luigi Vanvitelli, Monaldi Hosp, Dept Med Translat Sci, Div Cardiol, I-80131 Naples, Italy

[6] Univ Kentucky, Dept Med, Lexington, KY 40506 USA

来源：

MEDICINA-LITHUANIA | 2022年 / 58卷 / 04期

关键词：

COVID-19; atrial fibrillation; mortality risk; interleukin; 6; ISCHEMIC-STROKE; INFECTION;

D O I：

10.3390/medicina58040530

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and objectives: COVID-19 is associated with an aberrant inflammatory response that may trigger new-onset cardiac arrhythmias. The aim of this study was to assess the mortality risk in hospitalized COVID-19 patients according to IL-6 serum levels and new-onset atrial fibrillation (AF) according to PaO2/FiO(2) stratification. Materials and Methods: 175 COVID-19 patients (25 new-onset AF, 22 other types of AF and 128 no-AF) were included in this single-center, retrospective study; clinical and demographic data, vital signs, electrocardiograms and laboratory results were collected and analyzed. The primary outcome of the study was to evaluate the mortality rate in new-onset AF patients according to IL-6 serum levels and PaO2/FiO(2) stratification. Results: The incidence of new-onset AF in the study population was 14.2%. Compared to the no-AF group, new-onset AF patients were older with a positive history of chronic kidney disease and heart failure, had higher IL-6, creatinine and urea serum levels whereas their platelet count was reduced. After PaO2/FiO(2) stratification, 5-days mortality rate was higher in new-onset AF patients compared to patients with other types of AF and no-AF patients, and mortality risk increases 5.3 fold compared to no-AF (p = 0.0014) and 4.8 fold compared to other forms of AF (p = 0.03). Conclusions: New-onset AF is common in COVID-19 patients and is associated with increased IL-6 serum levels and early mortality. Further studies are needed to support the use of IL-6 as an early molecular target for COVID-19 patients to reduce their high rate of mortality.

引用

页数：12

共 49 条

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