An efficient and straight forward synthesis of (5S)-1-benzyl-5-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone (MM1): a novel antihypertensive agent

被引：9

作者：

Prasad, Jagdish ^{[1
]}

Pathak, Manoher Bhushan ^{[1
]}

Panday, Sharad Kumar ^{[1
]}

机构：

[1] MJP Rohilkhand Univ, Dept Chem, Fac Engn & Technol, Bareilly, Uttar Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 03期

关键词：

Hypertension; Angiotensin-II; AT(1) antagonists; MM1; Mitsunobu reaction; N-benzyl-5(S)-pyroglutaminol; TERMINAL AROMATIC RESIDUE; II RECEPTOR ANTAGONISTS; BIOLOGICAL EVALUATION; ANGIOTENSIN; DESIGN; CONFORMATION; DISCOVERY;

D O I：

10.1007/s00044-010-9536-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(5S)-1-benzyl-5-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone and its closely related analog was synthesized from (S)-pyroglutaminol and imidazole or substituted imidazole using Mitsunobu reaction as the key step.

引用

页码：321 / 324

页数：4

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