An efficient and straight forward synthesis of (5S)-1-benzyl-5-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone (MM1): a novel antihypertensive agent

被引：9
|
作者：
Prasad, Jagdish [1 ]
Pathak, Manoher Bhushan [1 ]
Panday, Sharad Kumar [1 ]
机构：
[1] MJP Rohilkhand Univ, Dept Chem, Fac Engn & Technol, Bareilly, Uttar Pradesh, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 03期
关键词：
Hypertension; Angiotensin-II; AT(1) antagonists; MM1; Mitsunobu reaction; N-benzyl-5(S)-pyroglutaminol; TERMINAL AROMATIC RESIDUE; II RECEPTOR ANTAGONISTS; BIOLOGICAL EVALUATION; ANGIOTENSIN; DESIGN; CONFORMATION; DISCOVERY;
D O I：
10.1007/s00044-010-9536-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(5S)-1-benzyl-5-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone and its closely related analog was synthesized from (S)-pyroglutaminol and imidazole or substituted imidazole using Mitsunobu reaction as the key step.
引用
收藏
页码：321 / 324
页数：4
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