Enhanced Cortisol Response to Stress in Children in Autism

被引：142

作者：

Spratt, Eve G. ^{[1
]}

Nicholas, Joyce S. ^{[1
]}

Brady, Kathleen T. ^{[1
]}

Carpenter, Laura A. ^{[1
]}

Hatcher, Charles R. ^{[1
]}

Meekins, Kirk A. ^{[1
]}

Furlanetto, Richard W. ^{[2
]}

Charles, Jane M. ^{[1
]}

机构：

[1] Med Univ S Carolina, Charleston, SC 29425 USA

[2] Nichols Inst Quest Diagnost, Chantilly, VA 20151 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2012年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Cortisol; Autism; Stress; HPA; Adaptability; Neurobiology; CHILDHOOD AUTISM; RATING-SCALE; SPECTRUM; DISORDER; HORMONE; ADULTS;

D O I：

10.1007/s10803-011-1214-0

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Children with Autism often show difficulties in adapting to change. Previous studies of cortisol, a neurobiologic stress hormone reflecting hypothalamic-pituitary-adrenal (HPA) axis activity, in children with autism have demonstrated variable results. This study measured cortisol levels in children with and without Autism: (1) at rest; (2) in a novel environment; and (3) in response to a blood draw stressor. A significantly higher serum cortisol response was found in the group of children with autism. Analysis showed significantly higher peak cortisol levels and prolonged duration and recovery of cortisol elevation following the blood-stick stressor in children with autism. This study suggests increased reactivity of the HPA axis to stress and novel stimuli in children with autism.

引用

页码：75 / 81

页数：7

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