In vivo near-realtime volumetric optical-resolution photoacoustic microscopy using a high-repetition-rate nanosecond fiber-laser

被引：48

作者：

Shi, Wei ^{[1
]}

Hajireza, Parsin ^{[1
]}

Shao, Peng ^{[1
]}

Forbrich, Alexander ^{[1
]}

Zemp, Roger J. ^{[1
]}

机构：

[1] Univ Alberta, Dept Elect & Comp Engn, Edmonton, AB T6G 2V4, Canada

来源：

OPTICS EXPRESS | 2011年 / 19卷 / 18期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

SENSITIVITY;

D O I：

10.1364/OE.19.017143

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Optical-resolution photoacoustic microscopy (OR-PAM) is capable of achieving optical-absorption-contrast images with micron-scale spatial resolution. Previous OR-PAM systems have been frame-rate limited by mechanical scanning speeds and laser pulse repetition rate (PRR). We demonstrate OR-PAM imaging using a diode-pumped nanosecond-pulsed Ytterbium-doped 532-nm fiber laser with PRR up to 600 kHz. Combined with fast-scanning mirrors, our proposed system provides C-scan and 3D images with acquisition frame rate of 4 frames per second (fps) or higher, two orders of magnitude faster than previously published systems. Highcontrast images of capillary-scale microvasculature in a live Swiss Webster mouse ear with similar to 6-mu m optical lateral spatial resolution are demonstrated. (C) 2011 Optical Society of America

引用

页码：17143 / 17150

页数：8

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