Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis

被引：118
|
作者：
Jureen, Pontus [1 ,2 ]
Werngren, Jim [1 ]
Toro, Juan-Carlos [1 ]
Hoffner, Sven [1 ]
机构：
[1] Swedish Inst Infect Dis Control, Dept Bacteriol, Solna, Sweden
[2] Karolinska Inst, Tumour & Cell Biol Ctr, Dept Microbiol, Stockholm, Sweden
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 05期
关键词：
D O I：
10.1128/AAC.00110-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive strains had any mutations, apart from silent mutations, whereas all but one resistant strain showed pncA mutations. By using sequencing as a means of early resistance detection, the inconsistency of phenotypic pyrazinamide assays can be circumvented.
引用
收藏
页码：1852 / 1854
页数：3
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