Strategy of selecting solvent systems for spherical agglomeration by the Lifshitz-van der Waals acid -base approach

被引：37

作者：

Chen, Mingyang ^{[1
]}

Liu, Xinyu ^{[1
]}

Yu, Changyou ^{[1
]}

Yao, Menghui ^{[1
]}

Xu, Shijie ^{[2
]}

Tang, Weiwei ^{[1
]}

Song, Xiaopeng ^{[1
]}

Dong, Weibing ^{[1
,3
]}

Wang, Gang ^{[3
]}

Gong, Junbo ^{[1
,3
,4
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China

[2] Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin Key Lab Marine Resources & Chem, Tianjin 300457, Peoples R China

[3] Qinghai Nationalities Univ, Sch Chem & Chem Engn, Xining 810007, Peoples R China

[4] Tianjin Univ, Key Lab Modern Drug Delivery & High Efficiency, Tianjin 300072, Peoples R China

来源：

CHEMICAL ENGINEERING SCIENCE | 2020年 / 220卷 / 220期

关键词：

CRYSTALLIZATION TECHNIQUE; SODIUM CEFOTAXIME; PARTICLE DESIGN; BENZOIC-ACID; MECHANISM; WETTABILITY; CRYSTALS; OPTIMIZATION; PARAMETERS; DROPLETS;

D O I：

10.1016/j.ces.2020.115613

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A strategy for rationally selecting solvent systems of spherical agglomeration is proposed for the first time. It emphasizes that followed by crystallization and phase separation, spherical agglomeration can be achieved only when the solvent system can induce wetting and adhesion which are estimated by the Lifshitz-van der Waals acid-base approach. Especially for wettability of bridging liquid, solvent and anti-solvent, the strategy indicates that it is of great importance for a successful solvent system. Valid systems therefore are selected in the first place while invalid ones are removed effectively according to the wettability difference. Based on the strategy, valid solvent systems for cefotaxime sodium and benzoic acid spherical agglomeration were selected successfully from 720 and 2184 systems respectively without missing the reported systems. The strategy also predicted no valid systems for potassium chloride, maltitol and trisodium phosphate in the given solvent combinations, which agreed with the experiment results. © 2020 Elsevier Ltd

引用

页数：14

共 52 条

[1]

Adamson A.W., 1997, PHYS CHEM SURFACES

[2] Agglomeration and adhesion free energy of paracetamol crystals in organic solvents [J].

Alander, Eva M. ;

Rasmuson, Ake C. .

AICHE JOURNAL, 2007, 53 (10) :2590-2605

[3] Spherical agglomeration during crystallization of an active pharmaceutical ingredient [J].

Amaro-González, D ;

Biscans, B .

POWDER TECHNOLOGY, 2002, 128 (2-3) :188-194

[4] Micro total analysis systems. 2. Analytical standard operations and applications [J].

Auroux, PA ;

Iossifidis, D ;

Reyes, DR ;

Manz, A .

ANALYTICAL CHEMISTRY, 2002, 74 (12) :2637-2652

[5] Fast Transport of Water Droplets over a Thermo-Switchable Surface Using Rewritable Wettability Gradient [J].

Banuprasad, Theneyur Narayanaswamy ;

Vinay, Thamarasseril Vijayan ;

Subash, Cherumannil Karumuthil ;

Varghese, Soney ;

George, Sajan D. ;

Varanakkottu, Subramanyan Namboodiri .

ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (33) :28046-28054

[6] Influence of Crystallization Conditions on Crystal Morphology and Size of CaCO3 and Their Effect on Pressure Filtration [J].

Beck, Ralf ;

Andreassen, Jens-Petter .

AICHE JOURNAL, 2012, 58 (01) :107-121

[7] Pervaporation of Emulsion Droplets for the Templated Assembly of Spherical Particles: A Population Balance Model [J].

Chang, Emily P. ;

Braatz, Richard D. ;

Hatton, T. Alan .

AICHE JOURNAL, 2013, 59 (10) :3975-3985

[8] The time and location dependent prediction of crystal caking by a modified crystal bridge growth model and DEM simulation considering particle size and shape [J].

Chen, Mingyang ;

Yu, Changyou ;

Yao, Menghui ;

Liu, Xinyu ;

Xu, Shijie ;

Tang, Weiwei ;

Dong, Weibing ;

Gong, Junbo .

CHEMICAL ENGINEERING SCIENCE, 2020, 214

[9] Caking of crystals: Characterization, mechanisms and prevention [J].

Chen, Mingyang ;

Wu, Songgu ;

Xu, Shijie ;

Yu, Bo ;

Shilbayeh, Mohannad ;

Liu, Ya ;

Zhu, Xiaowen ;

Wang, Jingkang ;

Gong, Junbo .

POWDER TECHNOLOGY, 2018, 337 :51-67

[10] Spherical Crystallization and the Mechanism of Clopidogrel Hydrogen Sulfate [J].

Chen, Mingyang ;

Du, Shichao ;

Zhang, Teng ;

Wang, Qi ;

Wu, Songgu ;

Gong, Junbo .

CHEMICAL ENGINEERING & TECHNOLOGY, 2018, 41 (06) :1259-1265

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