Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids

被引：27
|
作者：
Sribalan, Rajendran [1 ]
Banuppriya, Govindharasu [1 ]
Kirubavathi, Maruthan [1 ]
Padmini, Vediappen [1 ]
机构：
[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2019年 / 1175卷
关键词：
Hybrid tetrazole; Antimicrobial; Anti-inflammatory; Molecular docking; Molecular orbitals; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; DERIVATIVES;
D O I：
10.1016/j.molstruc.2018.07.114
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), OFT calculations, the Molecular electrostatic potential (MEP) and ACME were investigated. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：577 / 586
页数：10
相关论文
共 50 条
  • [21] Novel indolotacrine hybrids as acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and molecular docking studies
    Babaee, Saeed
    Zolfigol, Mohammad Ali
    Chehardoli, Gholamabbas
    Faramarzi, Mohammad Ali
    Mojtabavi, Somayeh
    Akbarzadeh, Tahmineh
    Hariri, Roshanak
    Rastegari, Arezoo
    Homayouni Moghadam, Farshad
    Mahdavi, Mohammad
    Najafi, Zahra
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2023, 20 (05) : 1049 - 1060
  • [22] Discovery of novel Quinazoline based Thiazolotriazole hybrids as potential EGFR inhibitor: Synthesis, anticancer evaluation and in silico studies
    Farveen, M. D.
    Kalagara, Sudhakar
    Balraju, E.
    Jaysree, B.
    Shaik, Ayub
    Begum, Alia
    CHEMICAL BIOLOGY LETTERS, 2025, 12 (02):
  • [23] Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups
    Wang, Qi
    Liu, Jie
    Zhou, Zi-Dan
    Zhou, Ke-Xin
    Li, Fei
    Zhang, Qi-Wen
    Wang, Shou-Kai
    Wang, Wei
    Jin, Zhen
    Tang, You-Zhi
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) : 2078 - 2091
  • [24] Synthesis, biological evaluation and molecular docking studies of heterocycle encompassed benzoxazole derivatives as antimicrobial agents
    Rodrigues, Manuel
    Sharath, B. S.
    Bennehalli, Basavaraju
    Vagdevi, H. M.
    MATERIALS TODAY-PROCEEDINGS, 2022, 49 : 849 - 853
  • [25] 2-Chloroquinolinyl-thiazolidine-2,4-dione Hybrids as Potential α-Amylase Inhibitors: Synthesis, Biological Evaluations, and In Silico Studies
    Karmur, Sheetal B.
    Dholariya, Monil P.
    Patel, Anilkumar S.
    Karmur, Manisha B.
    Maliwal, Deepika
    Pissurlenkar, Raghuvir R. S.
    Bhalodia, Jasmin J.
    Kaneria, Mital J.
    Ambasana, Mrunal
    Bapodra, Atul H.
    Kapuriya, Naval P.
    CHEMISTRYSELECT, 2024, 9 (39):
  • [26] New Triazole-Isoxazole Hybrids as Antibacterial Agents: Design, Synthesis, Characterization, In Vitro, and In Silico Studies
    Bouzammit, Rachid
    Belchkar, Salim
    El Fadili, Mohamed
    Kanzouai, Youssra
    Mujwar, Somdutt
    Alanazi, Mohammed M.
    Chalkha, Mohammed
    Nakkabi, Asmae
    Bakhouch, Mohamed
    Gal, Emese
    Gaina, Luiza Ioana
    al Houari, Ghali
    MOLECULES, 2024, 29 (11):
  • [27] Thiazolotriazoles As Anti-infectives: Design, Synthesis, Biological Evaluation and In Silico Studies
    Purakkel, Umadevi Kizhakke
    Praveena, Ganji
    Madabhushi, Valli Y.
    Jadav, Surender Singh
    Prakasham, Reddy Shetty
    Varakala, Saiprasad Goud Dasugari
    Sriram, Dharmarajan
    Blanch, Ewan W.
    Maniam, Subashani
    ACS OMEGA, 2024, 9 (08): : 8846 - 8861
  • [28] Synthesis, theoretical investigations and biological evaluation of ibuprofen drug hybrids
    Tatheer, Adina
    Murtaza, Shahzad
    Kausar, Naghmana
    Altaf, Ataf Ali
    Kausar, Samia
    Ahmed, Safeer
    Muhammad, Shabbir
    Hussain, Amjad
    MEDICINAL CHEMISTRY RESEARCH, 2022, 31 (11) : 2032 - 2044
  • [29] New Coumarin-Pyrazole hybrids: Synthesis, Docking studies and Biological evaluation as potential cholinesterase inhibitors
    Benazzouz-Touami, Amina
    Chouh, Amina
    Halit, Sabrina
    Terrachet-Bouaziz, Souhila
    Makhloufi-Chebli, Malika
    Ighil-Ahriz, Karima
    Silva, Artur M. S.
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1249
  • [30] Uridine Derivatives: Synthesis, Biological Evaluation, and In Silico Studies as Antimicrobial and Anticancer Agents
    Munia, Nasrin S.
    Alanazi, Mohammed M.
    El Bakri, Youness
    Alanazi, Ashwag S.
    Mukhrish, Yousef E.
    Hasan, Imtiaj
    Kawsar, Sarkar M. A.
    MEDICINA-LITHUANIA, 2023, 59 (06):
12345