Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids

被引：27

作者：

Sribalan, Rajendran ^{[1
]}

Banuppriya, Govindharasu ^{[1
]}

Kirubavathi, Maruthan ^{[1
]}

Padmini, Vediappen ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2019年 / 1175卷

关键词：

Hybrid tetrazole; Antimicrobial; Anti-inflammatory; Molecular docking; Molecular orbitals; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; DERIVATIVES;

D O I：

10.1016/j.molstruc.2018.07.114

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), OFT calculations, the Molecular electrostatic potential (MEP) and ACME were investigated. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：577 / 586

页数：10

共 50 条

[1] Synthesis and biological studies of novel hydroxyacetophenone-tetrazole hybrids
Disli, Ali
Yucesoy, Esin Eylem
Ozturk, Ali
Dilek, Gulay
ORGANIC COMMUNICATIONS, 2023, 16 (02) : 75 - 86
[2] Quinazolinone-linked triazole conjugates: Synthesis, biological evaluation, and in silico studies
Mhetre, Udhav, V
Bhagat, Amruta N.
Londhe, Shyam, V
Salunke, Somesh S.
More, Rahul A.
Rathod, Sanket S.
Choudhari, Prafulla B.
Kishan P., Haval
JOURNAL OF MOLECULAR STRUCTURE, 2025, 1331
[3] Design, Synthesis, Antimicrobial Evaluation and in Silico Studies of Eugenol-Sulfonamide Hybrids
Azevedo-Barbosa, Helloana
do Vale, Bianca Pereira
Guidolin Rossi, Grazielle
dos Santos Siqueira, Fallon
Bordignon Guterres, Kevim
de Campos, Marli Matiko Anraku
dos Santos, Thiago
Anthony Hawkes, Jamie
Ferreira Dias, Danielle
Neiva Lavorato, Stefania
de Souza, Thiago Belarmino
Teixeira Carvalho, Diogo
CHEMISTRY & BIODIVERSITY, 2021, 18 (05)
[4] Synthesis and characterization of curcumin-sulfonamide hybrids: Biological evaluation and molecular docking studies
Banuppriya, Govindharasu
Sribalan, Rajendran
Padmini, Vediappen
JOURNAL OF MOLECULAR STRUCTURE, 2018, 1155 : 90 - 100
[5] Synthesis, in vitro biological evaluation and in silico molecular docking studies of novel β-lactam-anthraquinone hybrids
Mohamadzadeh, Masoud
Zarei, Maaroof
Vessal, Mahmood
BIOORGANIC CHEMISTRY, 2020, 95
[6] In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB
Hrast, Martina
Jukic, Marko
Patin, Delphine
Tod, Julie
Dowson, Christopher G.
Roper, David I.
Barreteau, Helene
Gobec, Stanislav
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 91 (06) : 1101 - 1112
[7] Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases
Durgun, Mustafa
Turkes, Cuneyt
Isik, Mesut
Demir, Yeliz
Sakli, Ali
Kuru, Ali
Guzel, Abdussamat
Beydemir, Sukru
Akocak, Suleyman
Osman, Sameh M.
AlOthman, Zeid
Supuran, Claudiu T.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35 (01) : 950 - 962
[8] Design, Synthesis, Biological Evaluation and in Silico Studies of Curcumin Pyrrole Conjugates
Gogoi, Nishi Gandha
Rahman, Aziza
Dutta, Pankaj
Saikia, Jiban
Baruah, Anupaul
Handique, Jyotirekha G.
CHEMISTRY & BIODIVERSITY, 2024, 21 (05)
[9] Synthesis, In Silico Docking Study, and Biological Evaluation of S-Alkylated 1,3,4-Oxadiazole Hybrids
Das, Vishwa B.
Poojary, Boja
Kamat, Vinuta
Sharma, Ankita
Chowdhury, Rajdeep
Hamzad, Shanavaz
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (05) : 927 - 942
[10] Synthesis, Biological Evaluation and In silico Studies of Compounds Based on Tryptophan-Naproxen-Triazole Hybrids
Srinivas, Suryapeta
Neeraja, Papigani
Banothu, Venkanna
Dubey, Pramod Kumar
Mukkanti, Khagga
Pal, Sarbani
CHEMISTRYSELECT, 2020, 5 (46): : 14741 - 14746

← 1 2 3 4 5 →