TGF-β signaling in cancer

被引：64
作者：
Gu, Shuchen [1 ]
Feng, Xin-Hua [1 ,2 ]
机构：
[1] Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China
[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2018年 / 50卷 / 10期
基金：
中国国家自然科学基金;
关键词：
TGF-beta; cancer; EMT; immune; cancer treatment; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; PROSTATE-CANCER; C-MYC; LY2157299; MONOHYDRATE; MEDIATED INDUCTION; BELAGENPUMATUCEL-L; TUMOR SUPPRESSION; PHASE-II; CELL;
D O I：
10.1093/abbs/gmy092
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Signals from the transforming growth factor-beta (TGF-beta) superfamily mediate a broad spectrum of cellular processes and are deregulated in many diseases, including cancer. TGF-beta signaling has dual roles in tumorigenesis. In the early phase of tumorigenesis, TGF-beta has tumor suppressive functions, primarily through cell cycle arrest and apoptosis. However, in the late stage of cancer, TGF-beta acts as a driver of tumor progression and metastasis by increasing tumor cell invasiveness and migration and promoting chemo-resistance. Here, we briefly review the mechanisms and functions of TGF-beta signaling during tumor progression and discuss the therapeutic potentials of targeting the TGF-beta pathway in cancer.
引用
收藏
页码：941 / 949
页数：9
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