Synthesis, structure, and PDE inhibiting activity of the anionic DNIC with 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiolyl, the nitric oxide donor

被引：9

作者：

Sanina, Natalia A. ^{[1
,2
,3
]}

Isaeva, Yuliya A. ^{[1
]}

Utenyshev, Andrey N. ^{[1
]}

V. Dorovatovskii, Pavel ^{[4
]}

Ovanesyan, Nickolai S. ^{[1
]}

Emel'yanova, Nina S. ^{[1
,2
]}

V. Pokidova, Olesya ^{[1
]}

V. Tat'yanenko, Liliya ^{[1
]}

V. Sulimenkov, Il'ya ^{[5
]}

Kotel'nikov, Alexandr I. ^{[1
,2
]}

Aldoshin, Sergey M. ^{[1
,2
]}

机构：

[1] RAS, Inst Problems Chem Phys, 1 Acad Semenov Av, Chernogolovka 142432, Moscow Region, Russia

[2] MV Lomonosov MSU, Fac Fundamental Phys Chem Engn, GSP-1, Moscow 119991, Russia

[3] Moscow Reg State Univ, Med Chem Sci Educ Ctr, 24 Vera Voloshina St, Mytishchi 141014, Moscow Region, Russia

[4] Kurchatov Inst, Natl Res Ctr, 1 Acad Kurchatov Sq, Moscow 123182, Russia

[5] RAS, Chernogolovka Branch, NN Semenov Fed Res Ctr Chem Phys, 1 Acad Semenov Av, Chernogolovka 142432, Moscow Region, Russia

来源：

INORGANICA CHIMICA ACTA | 2021年 / 527卷

关键词：

Nitric oxide donors; Dinitrosyl iron complex; 5-(3-pyridyl)-4H-1,2; 4-triazole-3-thiol; X-ray diffraction; Mossbauer spectroscopy; IR spectroscopy; UV-Vis spectroscopy; Amperometry; Electrospray mass-spectrometry; TDDFT; Fermentative activity; Phosphodiesterase; DINITROSYL IRON COMPLEXES; (FE(NO)(2))(9) DNICS; THIOLATE LIGANDS; NO; PHOSPHODIESTERASE; INTERCONVERSION; TRANSFORMATION; DERIVATIVES; CONVERSION; CLUSTERS;

D O I：

10.1016/j.ica.2021.120559

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new inhibitor of phosphodiesterase (PDE), i.e., nitric oxide (NO) donor, a water soluble DNIC Na[Fe (C7H5N4S)(2)(NO)(2)]center dot 2 center dot 5H(2)O (1), has been synthesized. The structure of the new complex, its physical-chemical properties in the solid state and in solutions have been studied experimentally (X-ray analysis, IR, UV-Vis, Mossbauer spectroscopy, mass-spectrometry, and amperometry) and theoretically (quantum-chemical modeling by DFT method).

引用

页数：18

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