Synthesis, structure, and PDE inhibiting activity of the anionic DNIC with 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiolyl, the nitric oxide donor

被引：9

作者：

Sanina, Natalia A. ^{[1
,2
,3
]}

Isaeva, Yuliya A. ^{[1
]}

Utenyshev, Andrey N. ^{[1
]}

V. Dorovatovskii, Pavel ^{[4
]}

Ovanesyan, Nickolai S. ^{[1
]}

Emel'yanova, Nina S. ^{[1
,2
]}

V. Pokidova, Olesya ^{[1
]}

V. Tat'yanenko, Liliya ^{[1
]}

V. Sulimenkov, Il'ya ^{[5
]}

Kotel'nikov, Alexandr I. ^{[1
,2
]}

Aldoshin, Sergey M. ^{[1
,2
]}

机构：

[1] RAS, Inst Problems Chem Phys, 1 Acad Semenov Av, Chernogolovka 142432, Moscow Region, Russia

[2] MV Lomonosov MSU, Fac Fundamental Phys Chem Engn, GSP-1, Moscow 119991, Russia

[3] Moscow Reg State Univ, Med Chem Sci Educ Ctr, 24 Vera Voloshina St, Mytishchi 141014, Moscow Region, Russia

[4] Kurchatov Inst, Natl Res Ctr, 1 Acad Kurchatov Sq, Moscow 123182, Russia

[5] RAS, Chernogolovka Branch, NN Semenov Fed Res Ctr Chem Phys, 1 Acad Semenov Av, Chernogolovka 142432, Moscow Region, Russia

来源：

INORGANICA CHIMICA ACTA | 2021年 / 527卷

关键词：

Nitric oxide donors; Dinitrosyl iron complex; 5-(3-pyridyl)-4H-1,2; 4-triazole-3-thiol; X-ray diffraction; Mossbauer spectroscopy; IR spectroscopy; UV-Vis spectroscopy; Amperometry; Electrospray mass-spectrometry; TDDFT; Fermentative activity; Phosphodiesterase; DINITROSYL IRON COMPLEXES; (FE(NO)(2))(9) DNICS; THIOLATE LIGANDS; NO; PHOSPHODIESTERASE; INTERCONVERSION; TRANSFORMATION; DERIVATIVES; CONVERSION; CLUSTERS;

D O I：

10.1016/j.ica.2021.120559

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new inhibitor of phosphodiesterase (PDE), i.e., nitric oxide (NO) donor, a water soluble DNIC Na[Fe (C7H5N4S)(2)(NO)(2)]center dot 2 center dot 5H(2)O (1), has been synthesized. The structure of the new complex, its physical-chemical properties in the solid state and in solutions have been studied experimentally (X-ray analysis, IR, UV-Vis, Mossbauer spectroscopy, mass-spectrometry, and amperometry) and theoretically (quantum-chemical modeling by DFT method).

引用

页数：18

共 82 条

[1] Formation of supramolecular synthons in the crystalline structure of the dinitrosyl iron complexes with aliphatic thiourea ligands
Aldoshin, S. M.
Bozhenko, K. V.
Utenyshev, A. N.
Sanina, N. A.
Emel'yanova, N. S.
[J]. JOURNAL OF MOLECULAR MODELING, 2020, 26 (11)
[2] A new class of nitric oxide donors
Aldoshin, S. M.
Sanina, N. A.
Davydov, M. I.
Chazov, E. I.
[J]. HERALD OF THE RUSSIAN ACADEMY OF SCIENCES, 2016, 86 (03) : 158 - 163
[3] Chemistry and Biological Activities of 1,2,4-Triazolethiones-Antiviral and Anti-Infective Drugs
Aly, Ashraf A.
Hassan, Alaa A.
Makhlouf, Maysa M.
Braese, Stefan
[J]. MOLECULES, 2020, 25 (13):
[4] [Anonymous], 2017, NITRIC OXIDE BIOL PA
[5] [Anonymous], 1955, Organic Solvents. Physical Properties and Methods of Purification
[6] Antonini E., 1971, NORTHHOLLAND RES MON
[7] Asif M., 2016, ORG CHEM CURR RES, V5, P4, DOI [10.4172/2161-0401.1000173, DOI 10.4172/2161-0401.1000173]
[8] Synthesis of the 17-electron cations [FeL(L')(NO)(2)](+) (L,L'=PPh(3), OPPh(3)): Structure and bonding in four-co-ordinate metal dinitrosyls, and implications for the identity of paramagnetic iron dinitrosyl complex catalysts
Atkinson, FL
Blackwell, HE
Brown, NC
Connelly, NG
Crossley, JG
Orpen, AG
Rieger, AL
Rieger, PH
[J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (17): : 3491 - 3502
[9] Bader R.F.W., 1998, ENCYCL COMPUT CHEM, V1, P64, DOI DOI 10.1002/0470845015
[10] A QUANTUM-THEORY OF MOLECULAR-STRUCTURE AND ITS APPLICATIONS
BADER, RFW
[J]. CHEMICAL REVIEWS, 1991, 91 (05) : 893 - 928

← 1 2 3 4 5 6 7 8 9 →