Comparison between capillary electrophoresis, liquid chromatography, potentiometric and spectrophotometric techniques for evaluation of pKa values of zwitterionic drugs in acetonitrile-water mixtures

被引：106

作者：

Barbosa, J ^{[1
]}

Barrón, D ^{[1
]}

Jiménez-Lozano, E ^{[1
]}

Sanz-Nebot, V ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

来源：

ANALYTICA CHIMICA ACTA | 2001年 / 437卷 / 02期

关键词：

zwitterionic quinolones; acid dissociation constant; capillary electrophoresis; liquid chromatography; potentiometry; UV-visible spectrophotometry;

D O I：

10.1016/S0003-2670(01)00997-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capillary electrophoresis, liquid chromatography, potentiometry and UV-visible spectrophotometry are frequently used for determination of pK(a) values of substances. In this work, we have compared the application of the different techniques to the determination of pK(a) values of a series of zwitterionic quinolones in acetonitrile-water mixtures, emphasizing the advantages of capillary electrophoresis for the determination of equilibrium constants of widely used drugs in aqueous and organic media. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：309 / 321

页数：13

共 49 条

[1] Highly selective and efficient separations of a wide range of acidic species in capillary electrophoresis employing non-aqueous media [J].

Altria, KD ;

Bryant, SM .

CHROMATOGRAPHIA, 1997, 46 (3-4) :122-130

[2]

BAKER DR, 1995, CAPILLARY ELECT

[3] Factor analysis applied to the correlation between dissociation constants and solvatochromic parameters in water-acetonitrile mixtures .1. Solvent effects on the dissociation of carboxylic acid groups in some diuretics, quinolones, buffers and peptides [J].

Barbosa, J ;

Fonrodona, G ;

Marques, I ;

Buti, S ;

Toro, I .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 1997, 16 (02) :104-111

[4] Protonation equilibria of quinolone antibacterials in acetonitrile-water mobile phases used in LC [J].

Barbosa, J ;

Berges, R ;

Toro, I ;

SanzNebot, V .

TALANTA, 1997, 44 (07) :1271-1283

[5] PREFERENTIAL SOLVATION IN ACETONITRILE-WATER MIXTURES - RELATIONSHIP BETWEEN SOLVATOCHROMIC PARAMETERS AND STANDARD PH VALUES [J].

BARBOSA, J ;

SANZNEBOT, V .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1994, 90 (21) :3287-3292

[6] Retention behaviour of quinolone derivatives in high-performance liquid chromatography -: Effect of pH and evaluation of ionization constants [J].

Barbosa, J ;

Bergés, R ;

Nebot, VS .

JOURNAL OF CHROMATOGRAPHY A, 1998, 823 (1-2) :411-422

[7] Solvatochromic parameter values and pH in aqueous-organic mixtures used in liquid chromatography - Prediction of retention of a series of quinolones [J].

Barbosa, J ;

Berges, R ;

SanzNebot, V .

JOURNAL OF CHROMATOGRAPHY A, 1996, 719 (01) :27-36

[8] Secondary chemical equilibria in high-performance liquid chromatography: influence of ionic strength and pH on retention of peptides [J].

Barbosa, J ;

Toro, I ;

Sanz-Nebot, V .

JOURNAL OF CHROMATOGRAPHY A, 1998, 823 (1-2) :497-509

[9] Electrophoretic behaviour of quinolones in capillary electrophoresis -: Effect of pH and evaluation of ionization constants [J].

Barbosa, J ;

Barrón, D ;

Jiménez-Lozano, E .

JOURNAL OF CHROMATOGRAPHY A, 1999, 839 (1-2) :183-192

[10] AUTOPROTOLYSIS CONSTANTS AND STANDARDIZATION OF THE GLASS-ELECTRODE IN ACETONITRILE WATER MIXTURES - EFFECT OF SOLVENT COMPOSITION [J].

BARBOSA, J ;

SANZNEBOT, V .

ANALYTICA CHIMICA ACTA, 1991, 244 (02) :183-191

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