miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5

被引：135

作者：

Miko, Edit ^{[1
]}

Margitai, Zoltan ^{[2
]}

Czimmerer, Zsolt ^{[1
]}

Varkonyi, Ildiko ^{[3
]}

Balazs Dezso ^{[3
]}

Lanyi, Arpad ^{[4
]}

Bacso, Zsolt ^{[2
]}

Scholtz, Beata ^{[1
]}

机构：

[1] UDMHSC, Clin Genom Ctr, Dept Biochem & Mol Biol, H-4010 Debrecen, Hungary

[2] UDMHSC, Dept Biophys & Cell Biol, H-4010 Debrecen, Hungary

[3] UDMHSC, Dept Pathol, H-4010 Debrecen, Hungary

[4] UDMHSC, Inst Immunol, H-4010 Debrecen, Hungary

来源：

FEBS LETTERS | 2011年 / 585卷 / 08期

基金：

匈牙利科学研究基金会;

关键词：

Small cell lung cancer; miR-126; SLC7A5; G1; delay; PROTEIN-KINASE-B; VASCULAR INTEGRITY; EXPRESSION; GROWTH; 3-KINASE; LAT1; MICRORNAS; TUMORS; MIRNA; MTOR;

D O I：

10.1016/j.febslet.2011.03.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite intensive efforts to improve therapies, small cell lung cancer (SCLC) still has a dismal median survival of 18 months. Since miR-126 is under-expressed in the majority of SCLC tumors, we investigated the effect of miR-126 overexpression on the proliferation and cell cycle distribution of H69 cells. Our results demonstrate that miR-126 inhibits proliferation of H69 cells, by delaying the cells in the G1 phase. Short interfering RNA (siRNA) mediated suppression of SLC7A5, a predicted target of mir-126, has the same effect on H69 cells. We also show for the first time that SLC7A5 is a direct target of miR-126. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1191 / 1196

页数：6

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