Synthesis, spectral analysis, and molecular modeling of bioactive Sn(II)-complexes with oxadiazole Schiff bases

被引：17

作者：

Khedr, Abdalla M. ^{[1
]}

Jadon, Sudha ^{[2
]}

Kumar, Vipin ^{[2
]}

机构：

[1] Tanta Univ, Fac Sci, Dept Chem, Tanta, Egypt

[2] Agra Coll, Dept Chem, Agra 282002, Uttar Pradesh, India

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2011年 / 64卷 / 08期

关键词：

Sn(II)-complexes; Oxadiazole Schiff bases; Molecular modeling; Antimicrobial activity; MANNICH-BASES; BIOLOGICAL-ACTIVITY; TIN(II) COMPLEXES; ISATIN; ANTIBACTERIAL; DERIVATIVES; ENVIRONMENT; ANTIFUNGAL; LIGANDS; CU(II);

D O I：

10.1080/00958972.2011.569541

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Sn(II)-complexes of seven 2-amino-5-substituted-aryl-1,3,4-oxadiazole Schiff bases have been synthesized and characterized by various physico-chemical studies. Their structures have been confirmed by elemental analyses, infrared, 1H NMR, UV-Vis, and mass spectral studies as well as thermal decomposition. Conductance measurements in methanol show these complexes to be non-electrolytes, and the molecular weight determinations support the proposed molecular formulae. The molecular structures of the complexes have been optimized by CS Chem 3-D Ultra Molecular Modeling and Analysis Program showing tetrahedral geometry. The bio-efficacy of the complexes has been examined against the growth of bacteria (Escherichia coli and Staphylococcus aureus) and fungi (Aspergillus flavus and Candida albicans) invitro to evaluate their anti-microbial potential.

引用

页码：1351 / 1359

页数：9

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