Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases

被引：4

作者：

Marchenko, Mikhail ^{[1
]}

Thomson, Andrew ^{[1
]}

Ellis, Terri N. ^{[2
]}

Knuckley, Bryan ^{[1
]}

Causey, Corey P. ^{[1
]}

机构：

[1] Univ N Florida, Dept Chem, Jacksonville, FL 32224 USA

[2] Univ N Florida, Dept Biol, Jacksonville, FL 32224 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2015年 / 23卷 / 09期

关键词：

Agmatine deiminase; Agmatine catabolism; Activity-based protein profiling; ABPP probe; STREPTOCOCCUS-MUTANS UA159; GENE-CLUSTER; NITRIC-OXIDE; IN-VITRO; ARGININE; METABOLISM; ACTIVATION; RECEPTORS; DISCOVERY; DESIGN;

D O I：

10.1016/j.bmc.2015.03.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Agmatine deiminases (AgDs) catalyze the hydrolytic conversion of agmatine (decarboxylated arginine) to N-carbamoylputrescine with concomitant release of ammonia. These enzymes, which are encoded by some pathogenic bacterial species, confer a competitive survival advantage by virtue of energy production and acid tolerance through agmatine catabolism. Herein we report the development of a clickable activity-based protein profiling (ABPP) probe that targets the AgD encoded by Streptococcus mutans with high selectivity and sensitivity. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2159 / 2167

页数：9

共 25 条

[1] Chlorella viruses contain genes encoding a complete polyamine biosynthetic pathway
Baumann, Sascha
Sander, Adrianne
Gurnon, James R.
Yanai-Balser, Giane M.
Van Etten, James L.
Piotrowski, Markus
[J]. VIROLOGY, 2007, 360 (01) : 209 - 217
[2] Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159
Griswold, AR
Jameson-Lee, M
Burne, RA
[J]. JOURNAL OF BACTERIOLOGY, 2006, 188 (03) : 834 - 841
[3] Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159
Griswold, AR
Chen, YYM
Burne, RA
[J]. JOURNAL OF BACTERIOLOGY, 2004, 186 (06) : 1902 - 1904
[4] Activity-based probes: discovering new biology and new drug targets
Heal, William P.
Dang, T. H. Tam
Tate, Edward W.
[J]. CHEMICAL SOCIETY REVIEWS, 2011, 40 (01) : 246 - 257
[5] Activity-based proteomic and metabolomic approaches for understanding metabolism
Hunerdosse, Devon
Nomura, Daniel K.
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 2014, 28 : 116 - 126
[6] Identification and characterization of plant agmatine iminohydrolase, the last missing link in polyamine biosynthesis of plants
Janowitz, T
Kneifel, H
Piotrowski, M
[J]. FEBS LETTERS, 2003, 544 (1-3) : 258 - 261
[7] Mechanistic Studies of Agmatine Deiminase from Multiple Bacterial Species
Jones, Justin E.
Dreyton, Christina J.
Flick, Heather
Causey, Corey P.
Thompson, Paul R.
[J]. BIOCHEMISTRY, 2010, 49 (43) : 9413 - 9423
[8] Characterization and inactivation of an agmatine deiminase from Helicobacter pylori
Jones, Justin E.
Causey, Corey P.
Lovelace, Leslie
Knuckley, Bryan
Flick, Heather
Lebioda, Lukasz
Thompson, Paul R.
[J]. BIOORGANIC CHEMISTRY, 2010, 38 (1-3) : 62 - 73
[9] Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells
Joshi, Mahesh S.
Ferguson, T. Bruce, Jr.
Johnson, Fruzsina K.
Johnson, Robert A.
Parthasarathy, Sampath
Lancaster, Jack R., Jr.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (24) : 9982 - 9987
[10] A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline
Knipp, M
Vasák, M
[J]. ANALYTICAL BIOCHEMISTRY, 2000, 286 (02) : 257 - 264

← 1 2 3 →