Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure-Activity Relationships

被引：18

作者：

Huang, Ying ^{[1
]}

Li, Gen ^{[2
]}

Hong, Chong ^{[1
]}

Zheng, Xia ^{[3
]}

Yu, Haiyang ^{[4
]}

Zhang, Yan ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Computat Chem Nat Antitumor Drug Res & De, Shenyang, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin, Peoples R China

[3] Liaoning Univ Tradit Chinese Med, Affiliated Hosp 2, Shenyang, Peoples R China

[4] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

steroidal alkaloids; structure-activity relationships; anticancer; drug design; medicinal potential; TUMOR-SUPPRESSOR; ANALOGS; CYCLOPAMINE; CHOLESTEROL; DENDROGENIN; DERIVATIVES; INHIBITORS; DISCOVERY; LEUKEMIA; SPONGE;

D O I：

10.3389/fonc.2021.733369

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal alkaloids have received special attention in anticancer activity recently. Substituted groups in chemical structure play markedly important roles in biological activities. Therefore, the effective way to obtain lead compounds quickly is structural modification, which is guided by structure-activity relationships (SARs). This review presents the SAR of steroidal alkaloids and anticancer, including pregnane alkaloids, cyclopregnane alkaloids, cholestane alkaloids, C-nor-D-homosteroidal alkaloids, and bis-steroidal pyrazine. A summary of SAR can powerfully help to design and synthesize more lead compounds.

引用

页数：17

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