Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

被引：20

作者：

de Korompay, Alanna ^{[2
]}

Hill, Jenny C. ^{[1
]}

Carter, James F. ^{[1
]}

NicDaeid, Niamh ^{[2
]}

Sleeman, Richard ^{[1
]}

机构：

[1] Mass Spec Analyt Ltd, Bristol BS99 7AR, Avon, England

[2] Univ Strathclyde, Ctr Forens Sci, Dept Pure & Appl Chem, Royal Coll, Glasgow G1 1XW, Lanark, Scotland

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1178卷 / 1-2期

基金：

英国工程与自然科学研究理事会;

关键词：

3,4-methylenedioxymethylamphetamine (MDMA); ecstasy tablets; supported liquid - liquid extraction (SLE); isotopic analysis; isotope ratio mass spectrometry (IRMS);

D O I：

10.1016/j.chroma.2007.11.054

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both delta C-13 and delta N-15. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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