Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus

被引：33
|
作者：
Kosai, Kosuke [1 ,2 ,3 ]
Seki, Masafumi [1 ,2 ,3 ]
Yanagihara, Katsunori [1 ]
Nakamura, Shigeki [1 ,2 ]
Kurihara, Shintaro [1 ]
Izumikawa, Koichi [1 ,2 ]
Kakeya, Hiroshi [1 ,2 ]
Yamamoto, Yoshihiro [1 ,2 ]
Tashiro, Takayoshi [1 ,2 ]
Kohno, Shigeru [1 ,2 ]
机构：
[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Nagasaki 8528501, Japan
[3] Kitakyushu City Yahata Hosp, Kitakyushu, Fukuoka, Japan
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2008年 / 40卷 / 04期
关键词：
D O I：
10.1080/00365540701660486
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Plasma levels of high mobility group box chromosomal protein-1 (HMGB-1), as well as of other inflammatory molecules such as interleukin-6 (IL-6), regulated on activation normal T-cell expressed and secreted (RANTES), and soluble intercellular adhesion molecule-1 (sICAM-1), were determined in patients with bacterial pneumonia coinfected with influenza virus. HMGB-1 levels were significantly elevated in these patients compared to patients undergoing mild bacterial pneumonia alone (p<0.01). Among cases of coinfection, we found a significant correlation between the concentration of HMGB-1 and white blood cell counts (p<0.05, r=0.612). Levels of IL-6 were also higher in these patients than in patients with bacterial pneumonia alone (p<0.05), despite similar levels of RANTES and sICAM-1 in the 2 groups. These data suggest that HMGB-1 is involved in the pathogenesis of severe bacterial pneumonia coinfected with influenza virus.
引用
收藏
页码：338 / 342
页数：5
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