Mechanisms of early placental development in mouse and humans

被引：332
作者：
Hemberger, Myriam [1 ,2 ,3 ,4 ,5 ]
Hanna, Courtney W. [4 ,5 ]
Dean, Wendy [1 ,2 ,4 ,6 ]
机构：
[1] Univ Calgary, Cumming Sch Med, Dept Biochem & Mol Biol, Calgary, AB, Canada
[2] Univ Calgary, Alberta Childrens Hosp, Res Inst, Calgary, AB, Canada
[3] Univ Calgary, Cumming Sch Med, Dept Med Genet, Calgary, AB, Canada
[4] Babraham Inst, Epigenet Programme, Babraham Res Campus, Cambridge, England
[5] Univ Cambridge, Ctr Trophoblast Res, Cambridge, England
[6] Univ Calgary, Cumming Sch Med, Dept Cell Biol & Anat, Calgary, AB, Canada
来源：
NATURE REVIEWS GENETICS | 2020年 / 21卷 / 01期
基金：
美国安德鲁·梅隆基金会;
关键词：
REPRESSIVE HISTONE METHYLATION; DNA-METHYLATION; STEM-CELLS; 1ST TRIMESTER; SELF-RENEWAL; ENDOGENOUS RETROVIRUSES; EXTRAEMBRYONIC ECTODERM; TROPHOBLAST DEVELOPMENT; EPIGENETIC RESTRICTION; ANIMAL-MODELS;
D O I：
10.1038/s41576-019-0169-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The importance of the placenta in supporting mammalian development has long been recognized, but our knowledge of the molecular, genetic and epigenetic requirements that underpin normal placentation has remained remarkably under-appreciated. Both the in vivo mouse model and in vitro-derived murine trophoblast stem cells have been invaluable research tools for gaining insights into these aspects of placental development and function, with recent studies starting to reshape our view of how a unique epigenetic environment contributes to trophoblast differentiation and placenta formation. These advances, together with recent successes in deriving human trophoblast stem cells, open up new and exciting prospects in basic and clinical settings that will help deepen our understanding of placental development and associated disorders of pregnancy.
引用
收藏
页码：27 / 43
页数：17
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