Organocatalytic asymmetric 5-hydroxypyrrolidine synthesis:: a highly enantioselective route to 3-substituted proline derivatives

被引：49
|
作者：
Rios, Ramon [1 ]
Ibrahem, Ismail [1 ]
Vesely, Jan [1 ]
Sunden, Henrik [1 ]
Cordova, Armando [1 ]
机构：
[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 49期
关键词：
D O I：
10.1016/j.tetlet.2007.10.028
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The highly enantioselective organocatalytic tandem reaction between 2-acylaminomalonates and alpha,beta-unsaturated aldehydes is presented. The reaction is a direct entry to 5-hydroxypyrrolidines and 3-substituted proline derivatives, which are furnished in high yields and 90-99% ee. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8695 / 8699
页数：5
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