Organocatalytic asymmetric 5-hydroxypyrrolidine synthesis:: a highly enantioselective route to 3-substituted proline derivatives

被引：49

作者：

Rios, Ramon ^{[1
]}

Ibrahem, Ismail ^{[1
]}

Vesely, Jan ^{[1
]}

Sunden, Henrik ^{[1
]}

Cordova, Armando ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 49期

关键词：

D O I：

10.1016/j.tetlet.2007.10.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly enantioselective organocatalytic tandem reaction between 2-acylaminomalonates and alpha,beta-unsaturated aldehydes is presented. The reaction is a direct entry to 5-hydroxypyrrolidines and 3-substituted proline derivatives, which are furnished in high yields and 90-99% ee. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8695 / 8699

页数：5

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