No audible wheezing: nuggets and conundrums from mouse asthma models

被引：75

作者：

Boyce, JA ^{[1
]}

Austen, KF ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 12期

关键词：

D O I：

10.1084/jem.20050584

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mouse models of T helper type 2 (Th2) cell-biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mouse strains. We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma.

引用

页码：1869 / 1873

页数：5

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