No audible wheezing: nuggets and conundrums from mouse asthma models

被引：75

作者：

Boyce, JA ^{[1
]}

Austen, KF ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 12期

关键词：

D O I：

10.1084/jem.20050584

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mouse models of T helper type 2 (Th2) cell-biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mouse strains. We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma.

引用

页码：1869 / 1873

页数：5

共 36 条

[11] Anti-interleukin 5 but not Anti-IgE prevents airway inflammation and airway hyperresponsiveness [J].

Hamelmann, E ;

Cieslewicz, G ;

Schwarze, J ;

Ishizuka, T ;

Joetham, A ;

Heusser, C ;

Gelfand, EW .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (03) :934-941

[12] A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model [J].

Henderson, WR ;

Tang, LO ;

Chu, SJ ;

Tsao, SM ;

Chiang, GKS ;

Jones, F ;

Jonas, M ;

Pae, C ;

Wang, HJ ;

Chi, EY .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (01) :108-116

[13] THE PRESENCE OF AIRWAY REACTIVITY BEFORE THE DEVELOPMENT OF ASTHMA [J].

HOPP, RJ ;

TOWNLEY, RG ;

BIVEN, RE ;

BEWTRA, AK ;

NAIR, NM .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (01) :2-8

[14] The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness [J].

Humbles, AA ;

Lu, B ;

Friend, DS ;

Okinaga, S ;

Lora, J ;

Al-garawi, A ;

Martin, TR ;

Gerard, NP ;

Gerard, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1479-1484

[15] A critical role for eosinophils in allergic airways remodeling [J].

Humbles, AA ;

Lloyd, CM ;

McMillan, SJ ;

Friend, DS ;

Xanthou, G ;

McKenna, EE ;

Ghiran, S ;

Gerard, NP ;

Yu, CN ;

Orkin, SH ;

Gerard, C .

SCIENCE, 2004, 305 (5691) :1776-1779

[16]

Ichinose Masakazu, 2004, Current Drug Targets - Inflammation and Allergy, V3, P263

[17] Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: Modulation by immunostimulatory DNA sequences [J].

Ikeda, RK ;

Miller, M ;

Nayar, J ;

Walker, L ;

Cho, JY ;

McElwain, K ;

McElwain, S ;

Raz, E ;

Broide, DH .

JOURNAL OF IMMUNOLOGY, 2003, 171 (09) :4860-4867

[18] A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease [J].

Kheradmand, F ;

Kiss, A ;

Xu, J ;

Lee, SH ;

Kolattukudy, PE ;

Corry, DB .

JOURNAL OF IMMUNOLOGY, 2002, 169 (10) :5904-5911

[19] Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice [J].

Kobayashi, T ;

Iijima, K ;

Kita, H .

JOURNAL OF IMMUNOLOGY, 2003, 170 (11) :5756-5763

[20] Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β1 [J].

Lee, CG ;

Homer, R ;

Zhou, Z ;

Lanone, Z ;

Wang, XM ;

Koteliansky, V ;

Shipley, JM ;

Gotwals, P ;

Noble, P ;

Chen, QS ;

Senior, RM ;

Elias, JA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (06) :809-821

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