Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment

被引：48

作者：

Huang, Yanyu ^{[1
]}

Wang, Hsiao-Chi ^{[2
]}

Zhao, Junwei ^{[1
]}

Wu, Ming-Heng ^{[3
,4
]}

Shih, Tsung-Chieh ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA

[2] Univ Calif Davis, Dept Internal Med, Sacramento, CA 95817 USA

[3] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Translat Med, Taipei 11031, Taiwan

[4] Taipei Med Univ, Coll Med Sci & Technol, Int PhD Program Translat Med, Taipei 11031, Taiwan

来源：

BIOMOLECULES | 2021年 / 11卷 / 10期

关键词：

Galectin-1; immunotherapy; microenvironment; LLS30; PROGNOSTIC-SIGNIFICANCE; TARGETING GALECTIN-1; PANCREATIC-CANCER; CLASSICAL HODGKIN; POOR-PROGNOSIS; HUMAN GLIOMAS; CELL; EXPRESSION; BINDING; PROGRESSION;

D O I：

10.3390/biom11101398

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.

引用

页数：13

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