Effect of vitamin C on glutathione and lipid peroxide levels in rats exposed to water-immersion restraint stress

被引：0
|
作者：
Alptekin, N [1 ]
Seçkin, S
Dogru-Abbasoglu, S
Koçak-Toker, N
Cevikbas, U
Uysal, M
机构：
[1] Univ Istanbul, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey
[2] Univ Istanbul, Istanbul Fac Med, Dept Pathol, TR-34390 Istanbul, Turkey
来源：
MEDICAL SCIENCE RESEARCH | 1998年 / 26卷 / 09期
关键词：
vitamin C; water-immersion restraint stress; lipid peroxide; glutathione; gastric ulcer; malondialdehyde;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We have investigated the effect of vitamin C (vit C) on malondialdehyde (MDA) and glutathione (GSH) levels in several tissues of rats treated with water-immersion restraint (WIR) stress. Hepatic and intestinal MDA levels increased significantly but GSH content remained unchanged after WIR stress. MDA levels declined following vit C supplementation. On the other hand, MDA and GSH levels were unchanged although ulcerogenic injury was seen in the stomach. Microscopically, this injury was reduced in the rats who received vit C. These results indicate that vit C may have a protective effect in stress-induced lipid peroxidation and gastric ulceration. Med Sci Res 26:595-597 (C) 1998 Lippincott Wiliiams & Wilkins.
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收藏
页码：595 / 597
页数：3
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