An Autopsy Case of Multicentric Castleman Disease Presenting with Severe Jaundice

被引：1

作者：

Yamazaki, Yuichi ^{[1
]}

Yoshida, Yuka ^{[2
]}

Shimizu, Megumi ^{[1
]}

Kobayashi, Takeshi ^{[1
]}

Tojima, Hiroki ^{[1
]}

Sato, Ken ^{[1
]}

Kakizaki, Satoru ^{[1
,3
]}

Handa, Hiroshi ^{[4
]}

Yokoo, Hideaki ^{[2
]}

Uraoka, Toshio ^{[1
]}

机构：

[1] Gunma Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Maebashi, Gumma, Japan

[2] Gunma Univ, Dept Human Pathol, Grad Sch Med, Maebashi, Gumma, Japan

[3] Natl Hosp Org Takasaki Gen Med Ctr, Dept Clin Res, Takasaki, Gumma, Japan

[4] Gunma Univ, Dept Hematol, Grad Sch Med, Maebashi, Gumma, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 22期

关键词：

autopsy; multicentric Castleman disease; severe jaundice; interleukin-6; LYMPH-NODE HYPERPLASIA; INTERLEUKIN-6;

D O I：

10.2169/internalmedicine.6835-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old man with multicentric Castleman disease (MCD) was admitted to our hospital with jaundice and ascites. Elevations in his bilirubin and interleukin-6 levels were noted, and computed tomography revealed hepatic atrophy and portal vein and bile duct disorders. Steroid therapy was started for MCD, but he died of hepatic failure. An autopsy revealed that the MCD activity was mild, but advanced fibrosis and cholestasis were observed in the liver. Mild infiltration of interleukin-6-positive plasma cells was noted in the highly fibrotic area of the liver. Although rare, liver and biliary tract damage may be also considered organ disorders of MCD.

引用

收藏

页码：3615 / 3620

页数：6

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