Vinyl aryl ethers from copper-catalyzed coupling of vinyl halides and phenols

被引：69

作者：

Wan, ZH ^{[1
]}

Jones, CD ^{[1
]}

Koenig, TM ^{[1
]}

Pu, YJ ^{[1
]}

Mitchell, D ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Global Chem Proc R&D, Indianapolis, IN 46285 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 45期

关键词：

D O I：

10.1016/j.tetlet.2003.09.068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general procedure for vinyl aryl ether bond formation by direct coupling of vinyl halides and phenols under mild Ullmann-type reaction conditions has been developed. Using copper chloride as the catalyst and cesium carbonate as the base, vinyl bromides or iodides were reacted with phenols in refluxing toluene to produce vinyl aryl ethers in good to excellent yields. (C) 2003 Elsevier Ltd. All riehts reserved.

引用

页码：8257 / 8259

页数：3

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