Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System

被引：32
作者：
Li, Zhixia [1 ]
Kawashita, Masakazu [1 ]
Araki, Norio [2 ]
Mitsumori, Michihide [3 ]
Hiraoka, Masahiro [3 ]
Doi, Masaaki [4 ]
机构：
[1] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi 9808579, Japan
[2] Kyoto Med Ctr, Natl Hosp Org, Kyoto 6128555, Japan
[3] Kyoto Univ, Grad Sch Med, Kyoto 6068507, Japan
[4] Tohoku Univ, Grad Sch Engn, Sendai, Miyagi 9808579, Japan
来源：
JOURNAL OF BIOMATERIALS APPLICATIONS | 2011年 / 25卷 / 07期
关键词：
magnetic iron oxide nanoparticles; oxidation-precipitation; initial molecular ratio of reactant; heating efficiency; hyperthermia of cancer; SOLID-STATE SYNTHESIS; MRI CONTRAST AGENT; GREEN-RUST; FE3O4; NANOPARTICLES; FERROUS HYDROXIDE; PRECIPITATION; MECHANISM; FUNCTIONALIZATION; TEMPERATURE; REDUCTION;
D O I：
10.1177/0885328209351136
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Magnetic iron oxide nanoparticles (MIONPs) were synthesized in a FeCl2-NaNO3-NaOH aqueous system under various initial Fe2+/NO3- molar ratios (alpha) and Fe2+/OH- molar ratios (beta) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe2+/NO3-/OH- molar ratio of 3 : 1 : 5 led to the formation of magnetic nanoparticles mainly composed of magnetite (Fe3O4) and maghemite (gamma-Fe2O3). The 36 nm sized gamma-Fe2O3 and 413 nm sized Fe3O4 were obtained by changing the order in which NaNO3 was added to a NaOH solution. The in vitro heat generations of the resulting MIONPs in an agar phantom were measured under an alternating magnetic field (100 kHz, 23.9 kA/m). The temperature rise (Delta T) of the agar phantom for the 36 nm sized gamma-Fe2O3 was 55 degrees C in the first 140 s, with a concentration of 58 mg Fe/mL. Our results showed that it is possible to prepare MIONPs with high heating efficiencies under optimal conditions using the present method.
引用
收藏
页码：643 / 661
页数：19
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