Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl2-NaNO3-NaOH Aqueous System

被引：32

作者：

Li, Zhixia ^{[1
]}

Kawashita, Masakazu ^{[1
]}

Araki, Norio ^{[2
]}

Mitsumori, Michihide ^{[3
]}

Hiraoka, Masahiro ^{[3
]}

Doi, Masaaki ^{[4
]}

机构：

[1] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi 9808579, Japan

[2] Kyoto Med Ctr, Natl Hosp Org, Kyoto 6128555, Japan

[3] Kyoto Univ, Grad Sch Med, Kyoto 6068507, Japan

[4] Tohoku Univ, Grad Sch Engn, Sendai, Miyagi 9808579, Japan

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2011年 / 25卷 / 07期

关键词：

magnetic iron oxide nanoparticles; oxidation-precipitation; initial molecular ratio of reactant; heating efficiency; hyperthermia of cancer; SOLID-STATE SYNTHESIS; MRI CONTRAST AGENT; GREEN-RUST; FE3O4; NANOPARTICLES; FERROUS HYDROXIDE; PRECIPITATION; MECHANISM; FUNCTIONALIZATION; TEMPERATURE; REDUCTION;

D O I：

10.1177/0885328209351136

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Magnetic iron oxide nanoparticles (MIONPs) were synthesized in a FeCl2-NaNO3-NaOH aqueous system under various initial Fe2+/NO3- molar ratios (alpha) and Fe2+/OH- molar ratios (beta) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe2+/NO3-/OH- molar ratio of 3 : 1 : 5 led to the formation of magnetic nanoparticles mainly composed of magnetite (Fe3O4) and maghemite (gamma-Fe2O3). The 36 nm sized gamma-Fe2O3 and 413 nm sized Fe3O4 were obtained by changing the order in which NaNO3 was added to a NaOH solution. The in vitro heat generations of the resulting MIONPs in an agar phantom were measured under an alternating magnetic field (100 kHz, 23.9 kA/m). The temperature rise (Delta T) of the agar phantom for the 36 nm sized gamma-Fe2O3 was 55 degrees C in the first 140 s, with a concentration of 58 mg Fe/mL. Our results showed that it is possible to prepare MIONPs with high heating efficiencies under optimal conditions using the present method.

引用

页码：643 / 661

页数：19

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