Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging

被引：168

作者：

Wester, Hans Juergen ^{[1
]}

Keller, Ulrich ^{[2
]}

Schottelius, Margret ^{[1
]}

Beer, Ambros ^{[3
]}

Philipp-Abbrederis, Kathrin ^{[2
]}

Hoffmann, Frauke ^{[1
]}

Simecek, Jakub ^{[1
]}

Gerngross, Carlos ^{[3
]}

Lassmann, Michael ^{[4
]}

Herrmann, Ken ^{[4
]}

Pellegata, Natalia ^{[5
]}

Rudelius, Martina ^{[6
]}

Kessler, Horst ^{[7
,8
]}

Schwaiger, Markus ^{[3
]}

机构：

[1] Tech Univ Munich, Pharmaceut Radiochem, Garching, Germany

[2] Tech Univ Munich, Dept Med 3, D-80290 Munich, Germany

[3] Tech Univ Munich, Dept Nucl Med, D-80290 Munich, Germany

[4] Univ Hosp Wurzburg, Dept Nucl Med, Wurzburg, Germany

[5] Helmholtz Zentrum Munchen, Inst Pathol, Munich, Germany

[6] Univ Wurzburg, Inst Pathol, Comprehens Canc Ctr Mainfranken, Wurzburg, Germany

[7] Tech Univ Munich, Dept Chem, Inst Adv Study, Garching, Germany

[8] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah, Saudi Arabia

来源：

THERANOSTICS | 2015年 / 5卷 / 06期

关键词：

CXCR4; chemokine receptor; positron emission tomography; lymphoma; in vivo imaging; CHEMOKINE RECEPTOR CXCR4; HUMAN CANCER XENOGRAFTS; B-CELL LYMPHOMA; ANTAGONIST PLERIXAFOR; RADIATION-DOSIMETRY; PROGNOSTIC VALUE; POOR SURVIVAL; IN-VITRO; PET; PEPTIDES;

D O I：

10.7150/thno.11251

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor-4 (CXCR4) expression is an adverse prognostic factor. Early clinical studies suggest that targeting CXCR4 with suitable high-affinity antagonists might be a novel means for therapy. In addition to the preclinical evaluation of [Ga-68]Pentixafor in mice bearing human lymphoma xenografts as an exemplary CXCR4-expressing tumor entity, we report on the first clinical applications of [Ga-68]Pentixafor-Positron Emission Tomography as a powerful method for CXCR4 imaging in cancer patients. [Ga-68]Pentixafor binds with high affinity and selectivity to human CXCR4 and exhibits a favorable dosimetry. [Ga-68]Pentixafor-PET provides images with excellent specificity and contrast. This non-invasive imaging technology for quantitative assessment of CXCR4 expression allows to further elucidate the role of CXCR4/CXCL12 ligand interaction in the pathogenesis and treatment of cancer, cardiovascular diseases and autoimmune and inflammatory disorders.

引用

页码：618 / 630

页数：13

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