Human leukocyte antigen-C and killer immunoglobulin-like re-ceptors in reproductive medicine

被引:0
作者
Rodriguez de Frias, Edgard [1 ,2 ,3 ]
Fernandez-Arquero, Miguel [1 ,2 ,4 ]
Subhi-Issa, Nabil [1 ,2 ]
Del Olmo, Ainhoa [1 ,2 ]
Cristobal, Ignacio [5 ]
Angel Herraiz, Miguel [5 ]
Sanchez-Ramon, Silvia [1 ,2 ,4 ]
机构
[1] Hosp Clin San Carlos, Dept Inmunol Clin, IML, Madrid, Spain
[2] Hosp Clin San Carlos, IdISSC, Madrid, Spain
[3] Hosp Doce Octubre, Dept Inmunol, Madrid, Spain
[4] Univ Complutense Madrid, Dept Inmunol ENT & Oftalmol, Fac Med, Madrid, Spain
[5] Hosp Clin San Carlos, Dept Obstet & Ginecol, Madrid, Spain
来源
MEDWAVE | 2021年 / 21卷 / 10期
关键词
HLA-C; KIR; recurrent implantation failure; recurrent miscarriage; recurrent reproductive failure; natures killer cells (NK); MHC CLASS-I; DECIDUAL NK CELLS; HLA-C; SPIRAL ARTERIES; MATERNAL KIR; PHYSIOLOGICAL TRANSFORMATION; EXTRAVILLOUS TROPHOBLAST; GROWTH RESTRICTION; FETAL; RECEPTOR;
D O I
10.5867/medwave.2021.10.8484
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Proper communication between natural killer cells and the human leuko-cyte antigens of the embryonic trophoblast at the maternal-fetal interface during pregnancy is essential for successful reproduction. However, specific combinations of embryonic human leukocyte antigen-C with killer immu-noglobulin-like receptors on decidual natural killer cells (the immunological code of pregnancy) can be associated with obstetric morbidity and preg-nancy loss. This article presents an updated review of the mechanisms un-derlying the interaction between embryonic human leukocyte antigen-C and maternal killer immunoglobulin-like receptors and their relevance to the physiology and pathophysiology of human reproduction.
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页数:12
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