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Human leukocyte antigen-C and killer immunoglobulin-like re-ceptors in reproductive medicine
被引:0
|作者:
Rodriguez de Frias, Edgard
[1
,2
,3
]
Fernandez-Arquero, Miguel
[1
,2
,4
]
Subhi-Issa, Nabil
[1
,2
]
Del Olmo, Ainhoa
[1
,2
]
Cristobal, Ignacio
[5
]
Angel Herraiz, Miguel
[5
]
Sanchez-Ramon, Silvia
[1
,2
,4
]
机构:
[1] Hosp Clin San Carlos, Dept Inmunol Clin, IML, Madrid, Spain
[2] Hosp Clin San Carlos, IdISSC, Madrid, Spain
[3] Hosp Doce Octubre, Dept Inmunol, Madrid, Spain
[4] Univ Complutense Madrid, Dept Inmunol ENT & Oftalmol, Fac Med, Madrid, Spain
[5] Hosp Clin San Carlos, Dept Obstet & Ginecol, Madrid, Spain
来源:
MEDWAVE
|
2021年
/
21卷
/
10期
关键词:
HLA-C;
KIR;
recurrent implantation failure;
recurrent miscarriage;
recurrent reproductive failure;
natures killer cells (NK);
MHC CLASS-I;
DECIDUAL NK CELLS;
HLA-C;
SPIRAL ARTERIES;
MATERNAL KIR;
PHYSIOLOGICAL TRANSFORMATION;
EXTRAVILLOUS TROPHOBLAST;
GROWTH RESTRICTION;
FETAL;
RECEPTOR;
D O I:
10.5867/medwave.2021.10.8484
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Proper communication between natural killer cells and the human leuko-cyte antigens of the embryonic trophoblast at the maternal-fetal interface during pregnancy is essential for successful reproduction. However, specific combinations of embryonic human leukocyte antigen-C with killer immu-noglobulin-like receptors on decidual natural killer cells (the immunological code of pregnancy) can be associated with obstetric morbidity and preg-nancy loss. This article presents an updated review of the mechanisms un-derlying the interaction between embryonic human leukocyte antigen-C and maternal killer immunoglobulin-like receptors and their relevance to the physiology and pathophysiology of human reproduction.
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页数:12
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